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Mysimba 8mg/90mg
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Central acting weight loss


Mysimba is an effective oral weight loss aid used by patients who struggle to lose excess weight which puts them at risk of developing serious conditions. This medicine is available in tablet form which is a convenient method for lots of patients. Together with exercise and healthy eating, Mysimba can help you successfully lose weight to reach your healthy weight loss goal. You should also ensure that you are a suitable candidate for this type of weight loss aid, Mysimba is not suitable for those who are a healthy weight or underweight, you should be diagnosed as obese before taking this medicine.

In some patients, obesity is often related to the brain, many people eat when they are stressed or have excessive hunger and food cravings. Mysimba contains two active ingredients, naltrexone hydrochloride and bupropion hydrochloride, which work on the areas of the brain which control food intake and energy expenditure. These ingredients work together to change how you feel about food and appetite. Reducing your appetite results in less food intake which ultimately leads to weight loss, especially with a low calorie diet and regular exercise. Mysimba helps to control your food cravings and makes you feel less hungry so you can reduce your calorie intake and reduce your weight.

If you have been medically diagnosed as obese and you are over 18 years of age, Mysimba may be a suitable solution for you providing you have tried other methods such as exercising and having a low calorie diet but to no avail. If dieting alone has not proved successful for you, Mysimba can assist you in losing extra pounds to bring you to a healthy weight. However, you should always consult a doctor before taking this medicine to ensure your suitability.
Before you take any weight loss medication, it's important to ensure that this medicine is suitable for you, those who are not classed as obese should not use these types of weight loss aids. One way to tell if you are obese is by measuring your Body Mass Index (BMI) which works out whether your weight is healthy for you based on your height and weight. The ideal, healthy BMI range for adults is from 18-25, and a BMI of 30 or over is classed as medically obese.

It's important you get to know your BMI measurement as obesity can lead to potentially fatal conditions such as high cholesterol, high blood pressure, heart attack or stroke. It can also impede on your ability to lead a full and active life. Mysimba can help people with a BMI of over 30 to lose the extra weight alongside dieting and exercising.
Mysimba may also be suitable for those who have a BMI between 27 and 30 who have additional health conditions related to their weight such as high blood pressure or type 2 diabetes.

Although Mysimba is designed for those who have a BMI of over 30, your medical history and other medications may mean it isn't right for you.

Speak to your doctor before taking Mysimba if:

You are allergic to naltrexone hydrochloride, bupropion hydrochloride or any of the other ingredients listed in the patient information leaflet

You suffer from hypertension

You have a brain tumour

You have liver or kidney disease

You have a history of eating or mental disorders

You have a condition that causes fits

You drink alcohol heavily

Mysimba should also not be used to treat childhood obesity and should be used with caution in older patients over the age of 65.

If you are pregnant, think you may be pregnant, or are breastfeeding you should not take Mysimba, consult your doctor for further advice.
It's not recommended that you drink alcohol while taking Mysimba as there is an increased risk of seizures (fits). You should stop drinking alcohol if you are planning to take Mysimba, however, if you're a heavy drinker or alcoholic suddenly stopping alcohol without medical supervision may also cause seizures so it's important to be alcohol free in a controlled way before taking this medicine which is why it is not suitable for those who are alcohol dependent and drink heavily.

Alcohol is also known to cause weight gain so it is more beneficial for you to stop or reduce your alcohol intake to help you achieve your weight loss goals.

It's important to inform your doctor of any other medicines you may be taking before starting Mysimba whether that be prescription, over the counter, or any herbal remedies. In particular, Mysimba should not be taken with the following:

Any other medicines which contain bupropion or naltrexone

Medicines for depression or Parkinson's disease known as monoamine oxidase inhibitors

Opiates or any medicines containing opiates

This is not an exhaustive list and there are many more listed on the patient information leaflet so please do check that there aren't any other interactions between Mysimba and any other medicines you're taking by reading the patient information leaflet and informing your doctor.
Your dose of Mysimba will be adapted over the coming weeks and you will initially take one tablet once a day in the morning. Always follow your doctor's instructions when it comes to taking Mysimba as this will ensure it is effective and that you get the best results. You will take this medicine as follows:

First week: one tablet in the morning

Second week: one tablet in the morning and evening

Third week: two tablets in the morning and one in the evening

Fourth week onwards: two tablets each morning and evening

Swallow the tablets whole with food.

If you have not lost at least 5 percent of your initial body weight after 16 weeks your doctor may recommend stopping this treatment. Treatment may be continued unless you're experiencing side effects, if treatment is continued you may be monitored closely with regular blood tests.

What are the side effects of Mysimba?

Like all medications, Mysimba may have side effects, but not everyone gets them. Common side effects include:

Abdominal pain

Nausea and vomiting



Difficulty sleeping

Muscle pain

These are the most common side effects which are experienced in more than 1 in 10 people. There are many other possible side effects listed on the patient information leaflet, and if you experience any side effects or any negative changes to your health while taking Mysimba you should see your doctor for advice.

If you are having fits (seizures) or you are experiencing an allergic reaction with swelling of the eyes, face, lips, tongue or throat causing difficulty breathing, or anaphylaxis you should seek medical help immediately.

Mysimba is a type of weight loss aid medication and should only be taken under doctor's recommendations, and when lifestyle changes have not worked.
All consultations are performed by EU registered doctors.
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